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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]

[13] Early clinical trials showed that the peptide had to be injected about ten times a day due to its short half-life, so the company collaborated with Southern Research in the US to develop a depot formulation that would be injected under the skin, and release the peptide slowly

Hyperpigmentation can occur with frequent use, more pronounced in individuals with darker skin, though generally reversible upon discontinuation

doi:10.1111/obr.13717