And now I think one of them, I cant remember an early one is off patent
J Neurochem (2007) 103(3):110210.10.1111/j.1471-4159.2007.04802.x 141 YoshimatsuHItateyamaEKondouSTajimaDHimenoKHidakaSet alHypothalamic neuronal histamine as a target of leptin in feeding behavior
Additionally, the efficacy of BC in treating cerebral ischemia/reperfusion injury (CI/RI) is certain, particularly due to the components of bile pigments, bile acids, and amino acids that can interfere with the enzymatic cascade reaction of CI/RI through multiple components, targets, and pathways

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