Beneficial bacteria produce short-chain fatty acids (SCFAs) during fibre fermentation, which may stimulate L-cells to release GLP-1
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This convergence of intracellular signaling architecture despite divergent extracellular binding mechanisms is a key insight from the orforglipron structural studies
Result: Microbial imbalance in asthma patientsmarked by reduced -diversity, depletion of immunomodulatory taxa (e.g., Bifidobacterium, Faecalibacterium), and enrichment of pathobiontsdisrupts short-chain fatty acid (SCFA) and tryptophan metabolism, skewing Th17/Treg balance toward Th2-dominated inflammation and airway hyperresponsiveness
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