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Simultaneous modulatory effects on the prostaglandins system can be clearly envisaged by counteraction of NSAIDs toxicity (peripheral and central organ lesions, bleeding, thrombocytopenias [100,101,102,106], and in particular, leaky gut syndrome) [107] and interaction with many molecular pathways [103,104,105,107,108,109,110,111,112,113,114,115]