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The International Citicoline Trial on acUte Stroke (ICTUS) is a multicenter and double-blind study that assessed the effect of supplementing 2,298 patients with acute ischemic stroke with citicoline (2,000 mg/day) or a placebo for six weeks on several functional and neurologic outcomes and on mortality rate (94)

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The final metabolite of beta-oxidation is acetyl-CoA, which can enter the tricarboxylic acid cycle for ATP production

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