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Weight loss results vary based on individual factors, but clinical studies have shown significant reductions over several months when combined with a healthy diet and lifestyle changes

GLP-1 is also produced by pancreatic islet cells and neurons within the NTS of the brainstem.56 The peptide is rapidly degraded by dipeptidyl peptidase-4 into GLP-1 amide and subsequently cleared renally, resulting in a short half-life of approximately two minutes.47 Activation of the G protein-coupled GLP-1 receptor increases intracellular calcium concentrations within pancreatic islets, thereby promoting insulin exocytosis

If you want another perspective on GLP-1-supportive gut health, our article on GLP-1 probiotics and weight loss explores the connection in more detail

Jensen, L.J

Community sources and trial data describe these effects at 0.5 mg: Dry mouth (most common), insomnia (more common with afternoon or evening dosing, per community sources), elevated heart rate (5-10 bpm), constipation, mild mood elevation