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The search was performed across multiple electronic databases, including PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar, to ensure broad coverage of biomedical, pharmacological, and neuroscientific literature

this is paradoxical as severe and very severe patients are incapable of even the slightest exertion (39)

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Why it matters: In studies, MOTS-c increased LH, FSH and testosterone levels, which suggests a role in the regulation of female and male reproductive function and (possibly) obesity-related infertility

Prospective Covariate Control: Designing adequately powered prospective longitudinal studies capable of testing whether baseline microbial signatures predict treatment outcomes while strictly controlling for diet, metformin use, and weight loss dynamics