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Although small molecule or peptide-based inhibitors against individual NSPs have been extensively explored in the past 50 years, efforts of the pharmaceutical industry so far have created little impact in the clinic, except for AAT augmentation therapy in patients with emphysema and congenital AATD (191)
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While it has shown impressive results in animal studies (mostly on rats and rabbits), there is a significant lack of large-scale human clinical trials
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