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To evaluate the association between GSH levels and cognitive function scores, standardized linear regression models were built with age, education level, FWHM, and SNR of tNAA as covariates

Treatment should start urgently and should not be delayed for laboratory confirmation if neurological features strongly suggest B12 deficiency

Glutamate excitotoxicity can lead to increased production of neuronal nitrogen oxide synthase (nNOS) which in turn can lead to higher production of reactive nitrogen species, damage to cellular components, and ultimately, cell death (Sullivan and Brown, 2005), and this is thought to be mediated by the oxidative stress triggered by excitotoxicity (Nguyen et al., 2011)

10.4103/NRR.NRR-D-24-00112 125 ZhuX.LuH.JiaH.WeiX.XueJ.LiW.et al (2025)

Assay: 98.0% to 101.0%