SHANK3 mutations are likely to cause mitochondrial dysfunction in PMS because six mitochondrial genes, including NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6 ), cytochrome c oxidase assembly ( SCO2 ), tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase ( TRMU ), thymidine phosphorylase ( TYMP ), carnitine palmitoyltransferase 1B ( CPT1B ), and aconitase 2 ( ACO2 ), are adjacent to SHANK3 in the 22q13.3 region [339]
You may be navigating side effects of the medication, such as nausea or food aversions, or simply have less of an appetite
While GLP-1 drugs improve insulin sensitivity and lower fasting glucose, ethanol can trigger unpredictable swingsrapid drops followed by sharp spikesthat undermine your treatment's benefits
Neither is broadly subsidised on the PBS for weight loss alone
The review also frames GLP-1RA use against the backdrop of rising obesity rates, substantial health care costs, and the high overlap between obesity and diagnosed diabetes