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Furthermore, adding to the complexity of this process, allosteric activators have been described that bind to sites distinct from the orthosteric binding pocket of the receptor (Zhao et al., 2020), thereby necessitating a highly precise preselection of compounds to be used as lead candidates

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After their synthesis within the cell, GSSG and glutathione S -conjugates may be exported from cells, a process that is mediated mainly by the multidrug resistance-associated proteins (MRP/ABCC)

17.4 (a, b) Schwannoma of the left intervertebral foramen L5S1 in a 53-year-old male: (a) axial T1-WI shows a dumbbell-shaped lesion which causes erosion of the body of L5 and the left facet joint, resulting in widening of the left intervertebral foramen

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