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The genes and cell signaling pathways related to the cell cycle, DNA repair cell death, mitochondria, immunity, nutrient signaling and the growth hormone Insulin Growth Factor-1 (IGF-1) mediated via the PI3K/AKT/mTOR (phosphoinositide 3-kinase/AKT (protein kinase B)/mammalian target for rapamycin) pathway have received extensive investigations as targets for anti-aging strategies (36, 52, 53)

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More importantly, metformin monotherapy may be particularly beneficial for patients with PCOS in late childhood and early adolescence, as well as those who are averse to oral contraceptives

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