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Progress tends to continue throughout the first year of treatment

Christensen MB, Gasbjerg LS, Heimbrger SM, Stensen S, Vilsbll T, Knop FK

Variants in B12 metabolism genes (MTHFR, transcobalamin) and fat metabolism pathways may influence absorption and lipotropic efficacy

Evidence from high-income settings indicates that even moderate increases in fish consumption led to substantial improvements in DHA levels, whereas in middle-income countries, available data show greater variability and limited intake consistency

However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease