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That loss of muscle mass means potentially losing gains in performance and metabolic rate

Women of childbearing potential should use effective contraception while using tirzepatide

The only direct head-to-head trial comparing tirzepatide and semaglutide (SURMOUNT-5) was conducted in individuals with obesity without T2DM and evaluated maximum tolerated doses rather than the full range of clinically relevant dosing strategies [8]

This gap reflects a combination of limited clinician familiarity with prescribing guidelines, concerns about medication safety, and barriers to insurance coverage

Increased gene expression of growth associated protein-43 in skin of patients with early-stage peripheral neuropathies