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These advances will rely heavily on the integration of organ-on-chip platforms and digital twin models, enabling continuous in vitro and in silico validation of therapeutic decisions before patient application

Generation of pAcF rotamer libraries The conformational flexibility of the pAcF was modeled by generating a rotamer library, which includes possible side-chain conformations

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A block in autophagy could also result in a defect in SG clearance [35, 36] and is the method of SG retention with the known autophagy inhibitor chloroquine [18]

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