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Abstract Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such as cellular proliferation, differentiation and development

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Zonulin is then secreted into the intestinal lumen activates the epidermal growth factor receptor (EGFR) via protease-activated receptor 2 (PAR2)