Emerging evidence indicates that chronic exposure to addictive substances can induce or exacerbate depressive symptoms through reward circuitry alterations, neuroinflammation, altered hypothalamic pituitary adrenal axis function, and mitochondrial dysfunction, thereby establishing a neurobiological milieu that favors drug induced depressive states
In contrast, the PSmatched population in our study had a mean age of 59.3 years, 50.450.8% were female, with an HbA1c of 8.68.7%, and a BMI of 35.135.2 kg/m
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, (Wegovy) (Mounjaro) , 1
2) This study performed by researchers Heffernan et al explored the chronic and acute metabolic effects of AOD9604 in several mouse models, including lean C57BL/6J, ob/ob, WT, and 3-KO mice