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The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S

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8.5 Mitochondrial complex V and epilepsy Mitochondrial complex V, also known as ATP synthase, is essential for mitochondrial energy production and comprises two functional domains: F1 and F0

Abstract Hypertension, or persistently elevated blood pressure, affects about one third of the adult population worldwide and causes approximately 8.5 million deaths annually