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Most patients rate nausea during peak weeks as the most challenging symptom, but its manageable with medication and resolves by week 12 for the majority

Most of the trials were rated to have a high risk of bias or some concerns

Given that sensory or gastrointestinal adverse effects, such as dysgeusia and persistent nausea, can impair nutritional intake and lead to early treatment discontinuation (particularly in vulnerable populations) future research must incorporate rigorous sensory testing, larger and more diverse cohorts, and adherence-related outcomes to clarify how incretin therapies influence taste perception and long-term eating behavior (153, 157, 161)

In some embodiments, each medium chain fatty acid independently comprises 8 to 12 carbon atoms in the carbon chain

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