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It initiates a cascade of deleterious changes, including impaired energy metabolism, enhanced ROS production, and intracellular calcium overload

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Induction of senescence is a protective response, as it avoids the replication of aged, damaged and cancerous cells

The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks