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A greater proportion of PDAC-associated diabetes in NOD individuals occur within 0 to 12, 12 to 24, and 24 to 36 months prior to PDAC diagnosis, while similar proportions of PDAC-associated diabetes and control populations occur past 36 months, thus establishing the criticality of diabetes presentation 3 years before PDAC as a window of opportunity for early detection ( Figure 4A ) (91)

J Exp Med 2013

Deprivation of cardiac energy leads to cardiac contractile dysfunction, left ventricular remodeling, and even heart failure (HF)

The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals