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Notably, addition of an FGF21 nAb diminished the GCGR mAb-mediated regulation of beta cell identity in vitro, and the effect of increased beta cell mass induced by GCGR mAb was attenuated in FGF21 nAb-treated db/db mice, Fgf21 / diabetic mice and Fgf21 Hep/ diabetic mice

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