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Recent studies based on machine learning identified different families of compounds already known to target SnCs, such as cardiac glycosides 38 or molecules mimicking the combination of dasatinib/quercetin 39 , confirming the real potential of this technique

Other products that are in mid- to late-stage studies for NASH are Zealand Pharma & Boehringer Ingelheims dapiglutide & survodutide (BI 456906) as well as Altimmunes pemvidutide

nanoparticle and EV platforms have already delivered anti-YTHDF1 siRNA in vivo , reshaping myeloid/TAM programs and enhancing therapy in liver cancer models

Thus, suggesting that both substrates are reduced via the same mechanism

The use of different methodologies yielded complementary findings but also allowed a critical view on performance and inherent limitations of each method