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Conversely, from a harm reduction perspective, advocates argue that ENDS provide a safer alternative to smoking, especially for smokers who do not desire to quit or find it difficult to do so

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Trends Pharmacol Sci 13 : 177184

As more of the nicotine is absorbed by the body in high-dose exposure, symptoms transition to lethargy, depression, low blood pressure, normal or elevated heart rate, paralysis, respiratory depression or arrest, and death