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Most researchers report that cardiac awareness diminishes significantly after 6 months of stable dosing

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zaffagnini M., Michelet L., Marchand C., Sparla F., Decottignies P., Le Marchal P., Miginiac-Maslow M., Noctor G., Trost P., Lemaire S.D

Denmark provides an excellent example of how this can be done ( Reference Rasmussen, Carle and Jorgensen 33 )

Targeted delivery systems addressing PCO require systems that can target the capsular bag specifically, as topical drops often fail to reach this site in therapeutic concentrations