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These beneficial effects were linked to enhanced formation of filamentous actin (F-actin) and activation of key cytoskeletal signaling pathways, including focal adhesion kinase (FAK) and paxillin

The goal of this review is to emphasize the roles of low-resolution structural techniques in establishing the IDP field by showing some illustrative examples of IDPs they helped to discover in the years preceding the formal acceptance of the protein intrinsic disorder concept