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In addition, treatment with coumarins isolated from Hydrangea paniculata improved colonic integrity, decreased the Firmicutes-to-Bacteroidetes ratio, reduced the relative abundance of Allobaculum and Desulfovibrio , decreased uremic toxin precursors, and enhanced SCFA production in MN rats [136]

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Whether this is caused by a primary dopaminergic mechanism of action or indirectly by changes in other neurotransmitter systems, for example, glutamate or GABA, has not been ruled out [27]

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