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Clinical studies have confirmed that AOD-9604 does not stimulate IGF-1 production in any biological system tested, including human clinical trials monitoring serum IGF-1 levels over 24-week treatment periods

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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)

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