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Patients may be asked about: Medical history Current medications Symptoms Previous vitamin B12 treatment Existing health conditions The injection itself is typically administered by a trained healthcare professional in a clinical setting

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Depending on stimuli, microglia can adopt distinct phenotypes: the M1 pro-inflammatory state (induced by lipopolysaccharide and characterized by production of cytokines such as TNF-, IL-1, and IL-6) and the M2 anti-inflammatory state (induced by IL-4 or IL-13, promoting repair) [122, 123]

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