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The group of GPx enzymes, which play an irreplaceable role in the regulation of ROS homeostasis in vivo, has been thought to use GSH as a reducing agent to catalyze the reduction of H 2 O 2 or organic peroxides to generate water or corresponding alcohols, respectively [17]

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The mitochondrial enzymes that are significantly reduced in a mouse model that develops type 2 diabetes progressively include PC, cICD, NADH dehydrogenase, citrate synthase and ATP synthase [80]

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Samples were split for baseline and GCL activity measurements

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8 Comparison of the FAT-Kinase domain of mTORC1 in different states and the ATP position relative to other PIKKs

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Given anticipated clinical and methodological heterogeneity across studies, we employed random-effects models for all analyses

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