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Excessive alcohol intake has been demonstrated to increase PARP1 activity, resulting in a reduction of hepatic NAD + and SIRT1 activity (Huang et al

Alemany S, Avella-Garca C, Liew Z, Garca-Esteban R, Inoue K, Cadman T, et al

Additionally, there were 131 differential metabolites between the ESC and WKY group (Fig

A genome-wide screen reveals FSP1 as the warfarin-resistant VKR To identify VKR, we used a genome-wide CRISPR-Cas9 knockout library (Brunello), which is composed of 76,441 single guide RNAs (sgRNAs) targeting 19,114 genes in the human genome 18