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The SURMOUNT-1 clinical trial, which tested tirzepatide for weight loss in adults without diabetes, found that musculoskeletal complaints like back pain, arthralgia, and myalgia did not occur at significantly higher rates in the tirzepatide group compared to placebo

As expected based on its ability to sharply reduce the body weight and normalize the glucose levels, semaglutide lowered the risk of heart attacks, strokes and cardiovascular deaths by as much as 20%

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Vit-D is mainly known to regulate calcium/phosphate homeostasis and bone metabolism