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In addition, crizotinib potently inhibited HGF-stimulated endothelial cell survival or invasion and serum-stimulated tubulogenesis in vitro, suggesting that this agent also exhibits antiangiogenic properties [71, 72]

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Concurrent medications (metformin, PPIs, antibiotics) and underlying gastrointestinal conditions may cause diarrhoea coinciding with B12 supplementation

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