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Key Experimental Conclusion on GHK-Cu Efficacy In a professional in vitro cell experiment, cultured adult human dermal fibroblasts (HDFa) were incubated with GHK-Cu at concentrations of 0.01nM, 1nM and 100nM
However, when ROS production exceeds the capacity of cellular antioxidant defenses to remove these toxic agents, oxidative stress occurs, as confirmed by elevated specific biomarkers of oxidative damage in cyst fluid, including lactose dehydrogenase, lipid peroxidation, and 8-hydroxy-2-deoxyguanosine (126)
[DOI] [PMC free article] [PubMed] [Google Scholar] 246.Chrisnasari R., Hennebelle M., Vincken J.P., van Berkel W.J.H., Ewing T.A
10.1038/leu.2014.68 138 SettyB