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Topical forskolin application has been shown to induce melanogenesis in MC1R-deficient mice, resulting in persistent tanning and increased UV resistance

AOD-9604 (Advanced Obesity Drug peptide) is a research-grade peptide derived from the C-terminus of human growth hormone (HGH), specifically the 176191 amino acid sequence

Both are synthetic analogs of alpha-melanocyte-stimulating hormone (alpha-MSH) with the amino acid substitutions Nle4 and D-Phe7, which confer resistance to enzymatic degradation and enhanced MC1R receptor binding

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Metabolic processes related to GH signaling