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Cardiovascular risk2.4mg/wk The dose tested in the cardiovascular outcomes trial, which cut major adverse cardiovascular events by 20% in people with established cardiovascular disease and no diabetes

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Weekly dosing protocols are being investigated as alternatives

A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

doi: 10.1136/annrheumdis-2014-205809 307 CribbsAPTerlecki-ZaniewiczSPhilpottMBaardmanJAhernDLindowMet al