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Because GLP-1 cannot be deleted specifically without affecting the other products of the proglucagon gene including glucagon, attention has focused on the GLP-1 receptor gene which can be deleted independent of the glucagon receptor

Unregulated Product Risks Because MT-2 is not FDA-approved for any indication, all available product is unregulated

They also demonstrated that glucotoxicity resulted in cells that were less responsive to glucose, blunting glucose-induced actin dynamics and impeding ISG fusion 7

The absence of proliferation within the acinar or ductal compartments also relates to the current controversy about the potential risk for neoplastic proliferation in patients treated with GLP-1 analogues

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