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In addition to rare de novo variants, a recent genome-wide association study (GWAS) has identified 5 genome-wide-significant ASD loci [37]
doi:10.1016/j.pcl.2007.09.006
These beneficial effects arise through diverse, interconnected molecular and cellular pathways ( in vitro models of microglia and nerve injury (including zebrafish in vivo experiments, cerebral ischemia rat models, neuronal injury models, Alzheimers disease 5xFAD mouse models, and spinal cord injury rat models)
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