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The Ariad standard requires evidence that the inventor possessed the specific claimed subject matter not merely that they were working in the relevant field

Said differently, to significantly advance how we treat bipolar disorder, we will need to replace unidimensional (i.e., purely phenomenological diagnoses) and static (i.e., based on the assumption that the appearance and underlying pathophysiology of the disease do not evolve over time) diagnostic and treatment approaches with strategies that are dynamic and integrated (i.e., including elements such as psychotherapy, pharmacotherapy, exercise, nutrition, meditation, relationship healing, etc.) as well as multi-level (i.e., based on phenomenology, neuroimaging, and biochemical and genetic evaluation)

It's worth noting that about 1 in 12 people in clinical trials experienced diarrhea regardless of their dose

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