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Separately, GHK-Cu has been found to stimulate fibroblast proliferation while upregulating genes for collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural components of the skin's extracellular matrix and to modulate matrix metalloproteinases (MMPs) and their inhibitors, which supports balanced remodeling rather than excessive breakdown or fibrosis

Moreover, in comparison to wild-type psoriatic mice, NRF2-deficient psoriatic mice exhibited an increase in the expression of Il17a and Il23a in skin tissues

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Leu J-G, Lin C-Y, Jian J-H, Shih C-Y, and Liang Y-J

It is unknown whether dietary intake of histidine limits carnosine synthesis in vegetarians with or without -alanine supplementation