It has been shown that pharmacological inhibition or knockdown of a single mGSH transporter significantly sensitized neurons to oxidative and nitrosative stress (Wilkins et al., 2013)
The administration of PTER improves the antioxidant defenses of the brain by raising the levels of CAT, GSH and the activity of SOD (Naik et al., 2017) (Figure 3)
A 12-week randomized controlled trial in vegans and vegetarians with marginal deficiency (Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status, Del Bo and colleagues, Clinical Nutrition , 2018, 40 subjects) found that even a modest sublingual dose of about 50 mcg per day restored serum B12 and improved holotranscobalamin, methylmalonic acid, and homocysteine, which confirms that sublingual liquid B12 can correct a marginal deficiency in plant-based eaters
The recommended dosage is one tablet per day with a meal or as directed by a healthcare professional
If no improvement occurs after 3-4 weeks at appropriate doses, product quality may be an issue, or the condition may not respond to this approach
