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The activity of MMPs generates soluble and small extracellular-matrix fragments (e.g., biglycan, decorin, versican, fragments of fibronectin, hyaluronan), which can act as DAMPs

Animal studies and early human research suggest these peptides may speed tendon-to-bone healing, reduce inflammatory cell buildup, and support better pain and function

Collect cells by centrifugation at 200 g for 10 min at 4C

At least 6 animals were included in each group and all test subjects were maintained under standard conditions including a 12 hour light/12 hour dark schedule as well as ad libitum access to a standard GLP diet and fresh water

Research measuring inflammatory markers shows the combination lowers pro-inflammatory cytokines (IL-6, TNF-alpha) by 6080%, versus 3040% for either peptide alone translating to less pain, less swelling, and a faster return to function without sacrificing healing quality