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More serious reactions, such as anaphylaxis or hypokalaemia in those with certain conditions, are rare but not impossible

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See the full KLOW cycle-length guide for a comparison of 4-, 6-, 8-12-, and 16-week schedules

For the older patients (60+ years) specially with arteriosclerosis, possibility of circulatory collapse after administration should be kept in mind (30)

These quality parameters are especially relevant in studies where inflammatory signaling or immune interference must be carefully controlled