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The controlled release can be realized by several methods, such as the change of surface or core of the nanoparticle to release antioxidants in response to definite stimuli

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Nevertheless, as mentioned above, p62 also regulates cell survival via the NRF2 antioxidant response pathway: in particular, the interaction between p62 and KEAP1 is essential for p62-dependent NRF2 signalling [199, 248, 249]

A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease

Olson CE (1988)