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Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial -oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation (Filipek et al., 2004

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conducted a randomized, double-blind, placebo-controlled design, it was observed that the combination therapy of pioglitazone and metformin led to a reduction in the concentrations of citrulline and arginine (Irving et al., 2015)

Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro