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Astrocytes generate H 2 O 2 and NO via mitochondrial respiration and enzymes such as MAO-B, diamine oxidase, NADPH oxidases, and inducible nitric oxide synthase (iNOS) [359364]

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High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels

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