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In WEGOVY clinical trials in adults for weight reduction, severe gastrointestinal adverse reactions were reported more frequently among patients receiving WEGOVY (4.1%) than placebo (0.9%)

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For example, while the SUSTAIN-6 study included patients with proliferative DR (PDR) and diabetic macular edema (DME), other CVOTs, such as PIONEER 6, did not

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First, at position 8, an alanine amino acid is swapped for alpha-aminoisobutyric acid