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This is due to mitochondrial dysfunction after glutathione depletion, mitochondrial protein adduct formation, and mitochondrial oxidant stress

Nausea remains the most common side effect, even with the B12 addition

Figure 4 Figure 5 3.2 RLR-IFN-I signaling pathway Other than TLR7 and TLR9, RLRs, including RIG-I, melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2), serve as intracellular PRRs mainly involved in antiviral immune responses ( Figures 6 , 7 )

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