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GLP-1 medications mimic a hormone naturally produced in the gut, helping the body: Increase insulin secretion in response to meals Slow gastric emptying Suppress appetite and reduce cravings These mechanisms support a caloric deficit and help many patients lose weight when combined with lifestyle changes

[18] Frias JP, et al

At 72 weeks, people taking tirzepatide lost an average of 20.2% of their body weight, compared with 13.7% for those taking semaglutide

Changes in gut hormone and glucose concentrations in relation to hunger and fullness