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The SURMOUNT-3 trial, which added Tirzepatide after an intensive lifestyle lead-in, reported total weight reductions of up to 26.6%

However, at advanced stages of MASLD, this mitochondrial flexibility diminishes, leading to oxidative stress, inflammation, and release of mitochondrial damage-associated molecular patterns (mito-DAMPs), with mitochondrial DNA (mtDNA) fragments being one of their major components [66]

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In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving

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